publication . Article . Other literature type . 2010

Admixture Mapping Comes of Age

Winkler, Cheryl A.; Nelson, George W.; Smith, Michael W.;
Open Access
  • Published: 01 Sep 2010
Abstract
Admixture mapping is based on the hypothesis that differences in disease rates between populations are due in part to frequency differences in disease-causing genetic variants. In admixed populations, these genetic variants occur more often on chromosome segments inherited from the ancestral population with the higher disease variant frequency. A genome scan for disease association requires only enough markers to identify the ancestral chromosome segments; for recently admixed populations, such as African Americans, 1,500–2,500 ancestry-informative markers (AIMs) are sufficient. The method was proposed over 50 years ago, but the AIM panels and statistical method...
Subjects
free text keywords: Genetics(clinical), Genetics, Molecular Biology, Genome Scan, Bioinformatics, Chromosome, Population, education.field_of_study, education, Gene mapping, Genetic variation, Genetic admixture, Disease, Disease rates, Biology
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publication . Article . Other literature type . 2010

Admixture Mapping Comes of Age

Winkler, Cheryl A.; Nelson, George W.; Smith, Michael W.;