publication . Article . 2007

Eosinophils: from low- to high-affinity immunoglobulin E receptors

Monique Capron; A. Soussi Gounni; M. Morita; Marie-José Truong; Lionel Prin; Jean-Pierre Kinet; André Capron;
Open Access
  • Published: 14 May 2007 Journal: Allergy, volume 50, pages 20-23 (issn: 0105-4538, eissn: 1398-9995, Copyright policy)
  • Publisher: Wiley
Several experimental approaches have been used to identify immunoglobulin (IgE) binding molecules expressed by human eosinophils. After the description that Fc epsilon RII/CD23 identified on eosinophils could participate in IgE binding and IgE-mediated cytotoxicity, Mac2/epsilon binding proteins belonging to the S-type lectin family were also detected on human eosinophils. Anti-Mac2 monoclonal antibodies inhibited eosinophil-dependent cytotoxicity towards parasitic targets. More recently, Fc epsilon RI was demonstrated on human eosinophils from hypereosinophilic patients. The 3 components of Fc epsilon RI, alpha, beta and gamma chains, were detected in eosinophi...
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Medical Subject Headings: respiratory system
free text keywords: Immunology, Immunology and Allergy, Alpha chain, Immunoglobulin E, biology.protein, biology, Chemistry, Immunology, Receptor, CD23, Eosinophil peroxidase, Immune system, Monoclonal antibody, medicine.drug_class, medicine, Antibody
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