publication . Article . 1995

Eosinophils: from low‐ to high‐affinity immunoglobulin E receptors

Capron, M.; Abdelilah Soussi Gounni; Morita, M.; Truong, M. J.; Prin, L.; Kinet, J. -P; Capron, A.;
  • Published: 01 Jun 1995
  • Publisher: Wiley
Abstract
Several experimental approaches have been used to identify immunoglobulin (IgE) binding molecules expressed by human eosinophils. After the description that Fee RII/CD23 identified on eosinophils could participate in IgE binding and IgE‐mediated cytotoxicity, Mac2/ε binding proteins belonging to the S‐type lectin family were also detected on human eosinophits. Anti‐Mac2 monoclonal antibodies inhibited eosinophil‐dependent cytotoxicity towards parasitic targets. More recently, Fcε RI was demonstrated on human eosinophils from hypereosinophilic patients. The 3 components of Fcε RI, α, β and γ chains, were detected in eosinophils. The α chain of Fcε RI was shown to...
Subjects
Medical Subject Headings: respiratory system
free text keywords: Immune system, Immunology, Monoclonal antibody, medicine.drug_class, medicine, CD23, Eosinophil peroxidase, biology.protein, biology, Antibody, Lectin, Immunoglobulin E, Receptor, business.industry, business
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publication . Article . 1995

Eosinophils: from low‐ to high‐affinity immunoglobulin E receptors

Capron, M.; Abdelilah Soussi Gounni; Morita, M.; Truong, M. J.; Prin, L.; Kinet, J. -P; Capron, A.;