Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

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Le Blon, Debbie; Guglielmetti, Caroline; Hoornaert, Chloé; Quarta, Alessandra; Daans, Jasmijn; Dooley, Dearbhaile; Lemmens, Evi; Praet, Jelle; De Vocht, Nathalie; Reekmans, Kristien; Santermans, Eva; Hens, Niel; Goossens, Herman; Verhoye, Marleen; Van der Linden, Annemie; Berneman, Zwi; Hendrix, Sven; Ponsaerts, Peter;
  • Publisher: BioMed Central
  • Journal: Journal of Neuroinflammation, volume 13, issue 1 (issn: 1742-2094, eissn: 1742-2094)
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  • Identifiers: doi: 10.1186/s12974-016-0756-7, pmc: PMC5103449
  • Subject: Cellular and Molecular Neuroscience | Magnetic resonance imaging | Interleukin 13; Mesenchymal stem cells; Neuroinflammation; Transplantation; Magnetic resonance imaging | Interleukin 13 | Neuroinflammation | Mesenchymal stem cells | Transplantation | Immunology | Neurology | Human medicine | Research

Background: Promoting the neuroprotective and repair-inducing effector functions of microglia and macrophages, by means of M2 polarisation or alternative activation, is expected to become a new therapeutic approach for central nervous system (CNS) disorders in which det... View more
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