publication . Article . 2016

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Marleen Verhoye; Peter Ponsaerts; Dearbhaile Dooley; Caroline Guglielmetti; Annemie Van der Linden; Alessandra Quarta; Zwi N. Berneman; Jelle Praet; Evi Lemmens; Eva Santermans; ...
Open Access English
  • Published: 09 Nov 2016
  • Publisher: BIOMED CENTRAL LTD
  • Country: Belgium
Abstract
Background: Promoting the neuroprotective and repair-inducing effector functions of microglia and macrophages, by means of M2 polarisation or alternative activation, is expected to become a new therapeutic approach for central nervous system (CNS) disorders in which detrimental pro-inflammatory microglia and/or macrophages display a major contribution to the neuropathology. In this study, we present a novel in vivo approach using intracerebral grafting of mesenchymal stem cells (MSC) genetically engineered to secrete interleukin 13 (IL13-MSC). Methods: In the first experimental setup, control MSC and IL13-MSC were grafted in the CNS of eGFP(+) bone marrow chimae...
Subjects
free text keywords: Interleukin 13; Mesenchymal stem cells; Neuroinflammation; Transplantation; Magnetic resonance imaging, Research, Interleukin 13, Mesenchymal stem cells, Neuroinflammation, Transplantation, Magnetic resonance imaging, Immunology, Cellular and Molecular Neuroscience, Neurology, Human medicine, Gliosis, medicine.symptom, medicine, Cancer research, Neuroprotection, Oligodendrocyte, medicine.anatomical_structure, Biology, Mesenchymal stem cell, Microglia, Neuroscience, Microgliosis
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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