publication . Preprint . Other literature type . Article . 2019

Analysis and Control of Genetic Toggle Switches Subject to Periodic Multi-Input Stimulation

Fiore, Davide; Guarino, Agostino; di Bernardo, Mario;
Open Access
  • Published: 01 Apr 2019
  • Country: United Kingdom
Abstract
Comment: Preprint accepted for publication on L-CSS (First submission 31.05.2018, accepted 21.08.2018)
Subjects
free text keywords: Proteins, Genetics, Control systems, Sociology, Statistics, Cell (biology), Mathematical model, Proteins, Genetics, Control systems, Sociology, Statistics, Cell (biology), Mathematical model, FOS: Biological sciences, FOS: Sociology, FOS: Mathematics, genetic regulatory systems, modeling, Systems biology, Quantitative Biology - Molecular Networks, Electrical Engineering and Systems Science - Systems and Control, Periodic forcing, Control system, Multi input, Asymptotic analysis, Mean value, Biological system, System parameters, Periodic graph (geometry), Systems biology
Funded by
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020 | RIA
Validated by funder
Communities
FET H2020FET OPEN: FET-Open research and innovation actions
FET H2020FET OPEN: Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
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Zenodo
Other literature type . 2018
Provider: Datacite
Zenodo
Other literature type . 2018
Provider: Datacite

[1] U. Alon, An introduction to systems biology: design principles of biological circuits. CRC press, 2006.

[2] L. Chen, R. Wang, C. Li, and K. Aihara, Modeling biomolecular networks in cells. Springer-Verlag London, 2010.

[3] T. S. Gardner, C. R. Cantor, and J. J. Collins, “Construction of a genetic toggle switch in escherichia coli,” Nature, vol. 403, no. 6767, pp. 339- 342, 2000.

[4] T. Tian and K. Burrage, “Stochastic models for regulatory networks of the genetic toggle switch,” Proceedings of the National Academy of Sciences, vol. 103, no. 22, pp. 8372-8377, 2006. [OpenAIRE]

[5] M. Wu, R.-Q. Su, X. Li, T. Ellis, Y.-C. Lai, and X. Wang, “Engineering of regulated stochastic cell fate determination,” Proceedings of the National Academy of Sciences, vol. 110, no. 26, pp. 10 610-10 615, 2013.

[6] J.-B. Lugagne, S. S. Carrillo, M. Kirch, A. Ko¨hler, G. Batt, and P. Hersen, “Balancing a genetic toggle switch by real-time feedback control and periodic forcing,” Nature Communications, vol. 8, no. 1, p. 1671, 2017. [OpenAIRE]

mRN ALacI [7] H. K. Khalil, Nonlinear systems, 2002.

[8] A. Kuznetsov, M. Kaern, and N. Kopell, “Synchrony in a population of hysteresis-based genetic oscillators,” SIAM Journal on Applied mRN ATetR Mathematics, vol. 65, no. 2, pp. 392-425, 2004. [OpenAIRE]

[9] E. V. Nikolaev and E. D. Sontag, “Quorum-sensing synchronization of synthetic toggle switches: A design based on monotone dynamical systems theory,” PLoS Computational Biology, vol. 12, no. 4, p. e1004881, 2016.

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