Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4

Article English OPEN
Pepe, G.; Calderazzi, G.; De Maglie, M.; Villa, A.; Vegeto, E.;
  • Publisher: Springer Nature
  • Journal: Journal of Neuroinflammation, volume 11, issue 1 (issn: 1742-2094, eissn: 1742-2094)
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  • Identifiers: pmc: PMC4302702, doi: 10.1186/s12974-014-0211-6
  • Subject: Cellular and Molecular Neuroscience | alternative activation | Settore BIO/14 - Farmacologia | M2 polarization | centrally administered interleukin-4 | microglia | Immunology | alternative activation; centrally administered interleukin-4; M2 polarization; microglia | Research | Neurology

Background Acquisition of the M1 or M2 phenotypes by microglia has been shown to occur during the development of pathological conditions, with M1 activation being widely involved in neurotoxicity in relation with the anatomical localization and the reactivity of subtype... View more
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