Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

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Dean, Michael; Carrington, Mary; Winkler, Cheryl; Huttley, Gavin A.; Smith, Michael W.; Allikmets, Rando; Goedert, James J.; Buchbinder, Susan P.; Vittinghoff, Eric; Gomperts, Edward; Donfield, Sharyne; Vlahov, David; Kaslow, Richard A.; Saah, A. J.; Rinaldo, Charles; Detels, Roger; Multicenter Aids Cohort Study,; Study, Hemophilia Growth and Development; Multicenter Hemophilia Cohort Study,; Study, Multicenter Aids Cohort; San Francisco City Cohort,; Study, Multicenter Hemophilia Cohort; Alive Study,; Cohort, San Francisco City; O'Brien, Stephen J.;

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4+ T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 structural gene was mapped to human chromosome 3p21, and a 32-base pair deletion allele (CKR5Δ32) wa... View more
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