The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase

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Gao, Hong-Qiang; Boyer, Paul L.; Sarafianos, Stefan G.; Arnold, Edward; Hughes, Stephen H.;
(2000)

Treating HIV infections with drugs that block viral replication selects for drug-resistant strains of the virus. Particular inhibitors select characteristic resistance mutations. In the case of the nucleoside analogs 3TC and FTC, resistant viruses are selected with muta... View more
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