publication . Article . Other literature type . 1986

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

Neil L. Harrison; Jeffery L. Barker; Majewska; Steven M. Paul; Rochelle D. Schwartz;
Open Access
  • Published: 23 May 1986
Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone and 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10(-7) and 10(-5)M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat h...
free text keywords: Multidisciplinary, Ion channel complex, Endocrinology, medicine.medical_specialty, medicine, Steroid hormone, medicine.medical_treatment, GABA receptor, Neuroactive steroid, Pharmacology, Flunitrazepam, medicine.drug, Hormone, 5-alpha-Dihydroprogesterone, Internal medicine, Biology, Pregnanolone
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Article . 1986
Provider: ZENODO
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Other literature type . 1986
Provider: Datacite
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