Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats

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Keller, Thomas; Krzyczmonik, Anna; Forsback, Sarita; Picón, Francisco R. López; Kirjavainen, Anna K.; Takkinen, Jatta; Rajander, Johan; Cacheux, Fanny; Damont, Annelaure; Dollé, Frédéric; Rinne, Juha O.; Haaparanta-Solin, Merja; Solin, Olof;

Purpose Many neurological conditions result in the overexpression of the translocator protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are a particularly attractive c... View more
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