publication . Article . 2008

In vitro–in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks

Dimitrios G. Fatouros; Flemming Nielsen; Dionysios Douroumis; Leontios J. Hadjileontiadis; Anette Müllertz;
Open Access
  • Published: 01 Aug 2008
Abstract
The aim of the current study was to evaluate the potential of the dynamic lipolysis model to simulate the absorption of a poorly soluble model drug compound, probucol, from three lipid-based formulations and to predict the in vitro-in vivo correlation (IVIVC) using neuro-fuzzy networks. An oil solution and two self-micro and nano-emulsifying drug delivery systems were tested in the lipolysis model. The release of probucol to the aqueous (micellar) phase was monitored during the progress of lipolysis. These release profiles compared with plasma profiles obtained in a previous bioavailability study conducted in mini-pigs at the same conditions. The release rate an...
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free text keywords: Biotechnology, Pharmaceutical Science, General Medicine, Bioavailability, Absorption (pharmacology), Drug delivery, Probucol, medicine.drug, medicine, Lipolysis, Chemistry, Neuro-fuzzy, Chromatography, Pharmacology, In vivo, IVIVC
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