Efficient tritiation of the translocator protein (18kDa) selective ligand DPA-714

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Damont, Annelaure; Garcia-Argote, Sébastien; Buisson, David-Alexandre; Rousseau, Bernard; Dollé, Frédéric;
  • Subject: isotopic labelling | tritium | DPA-714 | TSPO 18 kDa | PBR | tritiodebromination | hydrogen-for-tritium exchange

DPA-714 (N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide) is a recently discovered fluorinated ligand of the translocator protein 18 kDa (TSPO). Labelled with the short-lived positron emitter fluorine-18, this structure is... View more
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