publication . Part of book or chapter of book . 2014

Transcriptomic biomarkers in safety and risk assessment of chemicals

David T. Szabo;
Open Access
  • Published: 02 Feb 2014
  • Publisher: Elsevier
Abstract
The use of transcriptomics as an early and specific marker for cellular responses resulting from various diseases and as a marker for exposure to chemicals and therapeutic agents has been increasing over recent years. Transcriptomic markers represent a continuum of cellular responses and can provide a linkage to mechanisms of cell injury, cell death, or carcinogenic transformation. While transcriptomics has been successful as a predictor of health outcomes for a number of clinical diseases, advance in the use of this technique in chemical risk assessments and drug safety assessments are more limited. Translation and application of these biomarkers for risk and s...
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free text keywords: Health outcomes, Biomarker (medicine), Biology, Transcriptome, Potential biomarkers, Chemical risk, Risk assessment, Potential toxicity, Bioinformatics, Cell injury
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