publication . Other literature type . Article . 1990

Mechanism Of Corticotropin And Camp Induction Of Mitochondrial Cytochrome P450 System Enzymes In Adrenal Cortex Cells.

Hanukoglu, Israel;
Open Access
  • Published: 01 Nov 1990
  • Publisher: Zenodo
We studied the kinetics of ACTH induction of mitochondrial P450scc, P450c11 and their electron transport proteins, adrenodoxin, and adrenodoxin reductase in bovine adrenal cortex cells in primary culture. The mRNA levels of these enzymes increase and reach a peak within 3-12 h after ACTH addition. The protein levels of adrenodoxin reductase and P450scc show an increase only nearly 24 h after ACTH addition. After ACTH addition, the intracellular level of cAMP reaches maximal levels within 5 min, and then decreases gradually over 60 min. Hence, we examined the effect of a pulse of ACTH or cAMP analogs on enzyme and mRNA levels. Exposure of the cells to ACTH for 1-...
Medical Subject Headings: endocrine systemhormones, hormone substitutes, and hormone antagonists
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Other literature type . 1990
Provider: Datacite
Other literature type . 1990
Provider: Datacite
Article . 1990
Provider: ZENODO
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