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Optimal Parameter Tuning of Feedback Controllers with Application to Biomolecular Antithetic Integral Control

Filo, Maurice; Khammash, Mustafa;
Open Access
Abstract
<p><strong>Abstract</strong></p> <p>We consider the deterministic setting of a general nonlinear plant in feedback with a nonlinear controller that is parameterized by a finite number of unknown constants to be tuned. This setting is particularly useful in applications where the architecture of the feedback controller is constrained to have a specific structure, but the controller parameters can be tuned to optimize a given performance measure (e.g. biomolecular controllers, PID controllers, etc.). We first cast the tuning problem as a dynamically constrained optimization problem, then we convert the latter to an unconstrained one by introducing a suitable nonl...
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Funded by
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020
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