publication . Article . 2014

An enzymatic approach to bifunctional chelating agents.

Paolo Minazzi; Luciano Lattuada; Ivan G. Menegotto; Giovanni B. Giovenzana;
Open Access
  • Published: 10 Jul 2014
Abstract
Bifunctional chelating agents (BFCAs) combine the complexing properties of a multidentate ligand with the presence of a free reactive functional group, mainly devoted to conjugation purposes. Indeed, products obtained by conjugation of a BFCA to a biomolecule and coordination of a suitable metal ion are widely applied in medicine nowadays as diagnostic and therapeutic agents. BFCAs are generally prepared through multi-step syntheses and with extensive application of protection–deprotection strategies, due to the large number of functional groups involved. Hydrolytic enzymes, with their unique chemoselectivity, provided the best results in the preparation of thre...
Subjects
free text keywords: Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry, Chemoselectivity, Denticity, Biomolecule, chemistry.chemical_classification, chemistry, Hydrolysis, Metal, visual_art.visual_art_medium, visual_art, Ligand, Bifunctional, chemistry.chemical_compound, Chelation
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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