publication . Other literature type . Article . 1998

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

Dustin, Ml; Olszowy, Mw; Holdorf, Ad; Li, Jun; Bromley, Shannon; Desai, Naishadh; Widder, Patricia; van der Merwe, Pa Anton; Rosenberger, Frederick; Anton van der Merwe, P.; ...
Open Access
  • Published: 01 Sep 1998
  • Publisher: Zenodo
  • Country: United Kingdom
Abstract
Abstract Recognition of antigen by T cells requires the formation of a specialized junction between the T cell and the antigen-presenting cell. This junction is generated by the recruitment and the exclusion of specific proteins from the contact area. The mechanisms that regulate these events are unknown. Here we demonstrate that ligand engagement of the adhesion molecule, CD2, initiates a process of protein segregation, CD2 clustering, and cytoskeletal polarization. Although protein segregation was not dependent on the cytoplasmic domain of CD2, CD2 clustering and cytoskeletal polarization required an interaction of the CD2 cytoplasmic domain with a novel SH3-c...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, CD2-Associated Protein, Cytoplasm, Cytoskeleton, Receptor, Molecular biology, Adhesion, Cell biology, T cell, medicine.anatomical_structure, medicine, Signal transducing adaptor protein, Immunological synapse formation, Biology, Biochemistry, Genetics and Molecular Biology(all)
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Zenodo
Other literature type . 1998
Provider: Datacite
Cell
Article
Provider: UnpayWall
Zenodo
Other literature type . 1998
Provider: Datacite
ZENODO
Article . 1998
Provider: ZENODO
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publication . Other literature type . Article . 1998

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

Dustin, Ml; Olszowy, Mw; Holdorf, Ad; Li, Jun; Bromley, Shannon; Desai, Naishadh; Widder, Patricia; van der Merwe, Pa Anton; Rosenberger, Frederick; Anton van der Merwe, P.; ...