A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Dustin, Ml; Olszowy, Mw; Holdorf, Ad; Li, Jun; Bromley, Shannon; Desai, Naishadh; Widder, Patricia; van der Merwe, Pa Anton; Rosenberger, Frederick; Anton van der Merwe, P.; Allen, Pm; Shaw, As;
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Recognition of antigen by T cells requires the formation of a specialized junction between the T cell and the antigen-presenting cell. This junction is generated by the recruitment and the exclusion of specific proteins from the contact area. The mechanisms that regulat... View more