Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

Article, Other literature type English OPEN
Guo, Tiannan; Li, Li; Zhong, Qing; Rupp, Niels J; Charmpi, Konstantina; Wong, Christine E; Wagner, Ulrich; Rueschoff, Jan H; Jochum, Wolfram; Fankhauser, Christian Daniel; Saba, Karim; Poyet, Cedric; Wild, Peter J; Aebersold, Ruedi; Beyer, Andreas;

It remains unclear to what extent tumor heterogeneity impacts on protein biomarker discovery. Here, we quantified proteome intra-tissue heterogeneity (ITH) based on a multi-region analysis of prostate tissues using pressure cycling technology and Sequential Windowed Acq... View more
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