publication . Article . 2016

Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors.

Borbély, S; Jocsak, Gergely; Moldovan, Kinga; Sedlak, Lucie; Preininger, Eva; Boldizsar, Imre; Toth, Attila; Atlason, Palmi T; Molnar, Elek; Vilagi, Ildiko;
Open Access
  • Published: 01 Jul 2016 Journal: Neurochemistry International, volume 97, pages 83-90 (issn: 0197-0186, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Lignans are biologically active phenolic compounds related to lignin, produced in different plants. Arctigenin, a dibenzylbutyrolactone-type lignan, has been used as a neuroprotective agent for the treatment of encephalitis. Previous studies of cultured rat cerebral cortical neurones raised the possibility that arctigenin inhibits kainate-induced excitotoxicity. The aims of the present study were: 1) to analyse the effect of arctigenin on normal synaptic activity in <i>ex vivo</i> brain slices, 2) to determine its receptor binding properties and test the effect of arctigenin on AMPA/kainate receptor activation and 3) to establish its effects on neuronal activity...
Subjects
free text keywords: Ionotropic glutamate receptors, Evoked field potentials, Rat, Brain slices, In vivo experiments, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, Cell Biology, Cellular and Molecular Neuroscience, NMDA receptor, Arctigenin, chemistry.chemical_compound, chemistry, Glutamate receptor, Neuroprotection, Biochemistry, AMPA receptor, Kainate receptor, Excitotoxicity, medicine.disease_cause, medicine, Ionotropic effect, Biology
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publication . Article . 2016

Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors.

Borbély, S; Jocsak, Gergely; Moldovan, Kinga; Sedlak, Lucie; Preininger, Eva; Boldizsar, Imre; Toth, Attila; Atlason, Palmi T; Molnar, Elek; Vilagi, Ildiko;