publication . Article . 2016

Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors

Sándor Borbély; Gergely Jócsák; Kinga Moldován; Éva Sedlák; Éva Preininger; Imre Boldizsár; Attila Tóth; Palmi T. Atlason; Elek Molnar; Ildikó Világi;
Open Access English
  • Published: 01 Jul 2016
  • Country: United Kingdom
Abstract
Lignans are biologically active phenolic compounds related to lignin, produced in different plants. Arctigenin, a dibenzylbutyrolactone-type lignan, has been used as a neuroprotective agent for the treatment of encephalitis. Previous studies of cultured rat cerebral cortical neurones raised the possibility that arctigenin inhibits kainate-induced excitotoxicity. The aims of the present study were: 1) to analyse the effect of arctigenin on normal synaptic activity in <i>ex vivo</i> brain slices, 2) to determine its receptor binding properties and test the effect of arctigenin on AMPA/kainate receptor activation and 3) to establish its effects on neuronal activity...
Subjects
free text keywords: Arctigenin, Ionotropic glutamate receptors, Evoked field potentials, Rat, Brain slices, In vivo experiments, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, Cell Biology, Cellular and Molecular Neuroscience, AMPA receptor, NMDA receptor, Biology, Neuroscience, Neuroprotection, Pharmacology, Excitotoxicity, medicine.disease_cause, medicine, Kainate receptor, Ionotropic effect, Glutamate receptor, chemistry.chemical_compound, chemistry
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