Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death

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Nolasco, Sofia; Bellido, Javier; Gonçalves, João; Zabala, Juan Carlos; Soares, Helena;
  • Publisher: Elsevier
  • Subject: Phenotype | Cell cycle | Gene silencing | Tubulin | Apoptosis | Microtubules | Caspase 7 | Actin cytoskeleton | Molecular chaperone | β-Tubulin cofactor A | Molecular chaperones | Microtubule-associated proteins | RNA, Small interfering

Microtubules are polymers of alpha/beta-tubulin participating in essential cell functions. A multistep process involving distinct molecular chaperones and cofactors produces new tubulin heterodimers competent to polymerise. In vitro cofactor A (TBCA) interacts with beta... View more
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