publication . Article . 2021

Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources

Martins, José Manuel; Bovo, Samuele; Schiavo, Giuseppina; Ribani, Anisa; Utzeri, Valerio,; Taurisano, Valeria; Ballan, Mohamad; Muñoz, Maria; Alves, Estefania; Araujo, Jose,; ...
English
  • Published: 01 Dec 2021
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a "One Health" perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants...
Subjects
free text keywords: MESH: Angiotensin-Converting Enzyme 2, MESH: Animals, MESH: Whole Genome Sequencing, MESH: Breeding, MESH: CD13 Antigens, MESH: Coronavirus Infections, MESH: Dipeptidyl Peptidase 4, MESH: Gene Frequency, MESH: Genetic Variation, MESH: Genetics, Population, MESH: High-Throughput Nucleotide Sequencing, MESH: Humans, MESH: INDEL Mutation, MESH: One Health, MESH: Polymorphism, Single Nucleotide, MESH: Receptors, Virus, MESH: Serine Endopeptidases, MESH: Sus scrofa, MESH: Swine, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
Communities
Funded by
EC| TREASURE
Project
TREASURE
DIVERSITY OF LOCAL PIG BREEDS AND PRODUCTION SYSTEMS FOR HIGH QUALITY TRADITIONAL PRODUCTS AND SUSTAINABLE PORK CHAINS
  • Funder: European Commission (EC)
  • Project Code: 634476
  • Funding stream: H2020 | RIA
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