publication . Thesis . 2011

Response of Peripheral Blood Lymphocytes from RAO-affected Horses to b2-Agonist Stimulation

Werner Becker, Marianne Patricia;
Open Access English
  • Published: 03 May 2011
  • Publisher: Virginia Tech
  • Country: United States
Recurrent airway obstruction (RAO) affects middle-age horses, inducing bronchoconstriction and airway inflammation. β2-agonists like salbutamol are used as treatment, promoting airway smooth muscle (ASM) relaxation and bronchodilation. In addition to ASM, inflammatory cells express the β2-adrenoreceptors (β2-AR). In other species, β2-agonists promote peripheral blood lymphocyte (PBL) cytokine expression towards a pro-inflammatory phenotype. RAO horses are a good model for evaluating chronic changes in human asthma. However, little is known about the effect of β2-agonist stimulation on equine PBL inflammatory response. The aims of this study were to develop ...
Medical Subject Headings: respiratory tract diseases
free text keywords: Horses, VASP, b2-adrenoreceptors
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Thesis . 2011
Provider: VTechWorks
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