publication . Doctoral thesis . 2017

Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models

Popielarczyk, Tracee;
Open Access
  • Published: 31 Aug 2017
  • Publisher: Virginia Tech
  • Country: United States
Abstract
Mesenchymal stem cells (MSCs) have great potential to improve clinical outcomes for many inflammatory and degenerative diseases through delivery of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined by microenvironmental cues, specifically dimensionality, topography, and cell-cell interactions. MSC responses of migration and differentiation are the focus of this dissertation. Cell migration occurs in several physiological and pathological processes; migration mode and cell signaling are determined by the environment and type of confinement in three-di...
Subjects
free text keywords: mesenchymal stem cells, regenerative medicine, differentiation, tendon, scaffolds, stem cell homing
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Doctoral thesis . 2017
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