publication . Doctoral thesis . 2013

The Design, Synthesis and Study of Mixed-Metal Ru,Rh and Os, Rh Complexes with Biologically Relevant Reactivity

Wang, Jing;
Open Access
  • Published: 23 Jan 2013
  • Publisher: Virginia Tech
  • Country: United States
Abstract
A series of mixed-metal bimetallic complexes [(TL)2M(dpp)RhCl2(TL)]3 (M = Ru and Os, terminal ligands (TL) = phen, Ph2phen, Me2phen and bpy, terminal ligands (TL) = phen, bpy and Me2bpy ), which couple one Ru or Os polyazine light absorber (LA) to a cis-RhIIICl2 center through a dpp bridging ligand (BL), were synthesized using a building block method. These are related to previously studied trimetallic systems [{(TL)2M(dpp)2RhCl2]5+, but the bimetallics are synthetically more complex to prepare due to the tendency of RhIII halide starting materials to react with diimine ligands to form cis-[Rh(NN)2Cl2]+ motifs. The bimetallic complexes, [(phen)2Ru(dpp)RhCl2(bpy)...
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free text keywords: photodynamic therapy, mixed-metal, polyazine, DNA photocleavage, DNA photobinding, rhodium
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