publication . Thesis . 2012

Inactivation of Stac3 causes skeletal muscle defects and perinatal death in mice

Reinholt, Brad Michael;
Open Access English
  • Published: 27 Jan 2012
  • Publisher: Virginia Tech
  • Country: United States
Abstract
The Src homology 3 domain (SH3) and cysteine rich domain (C1) 3 (Stac3) gene is a novel gene copiously expressed in skeletal muscle. The objective of this research was to determine the role of Stac3 in development, specifically in skeletal muscle. We achieved this objective by evaluating the phenotypic effects of Stac3 gene inactivation on development in mice. At birth homozygous Stac3 null (Stac3-/-) mice died perinatally and remained in fetal position with limp limbs, but possessed otherwise normal organs based on gross and histological evaluations. The primary phenotypes displayed at term in Stac3-/- mice were reduced late gestational body weights, increased ...
Subjects
free text keywords: SH3 domain, C1 domain, myogenesis, SH3 and cysteine rich domain 3 (Stac3)
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Thesis . 2012
Provider: VTechWorks
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