publication . Patent . 1996

Production of lysosomal enzymes in plant-based expression systems

Open Access English
  • Published: 13 Sep 1996
  • Publisher: United States Patent and Trademark Office
  • Country: United States
The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants having recombinant expression constructs comprising human hGC and IDUA nucleotide sequences produced enzymatically active modified human glucocereb...
free text keywords: 435/69.1, 435/183, 435/206, 435/320.1, 435/410, 435/414, 536/23.1, 536/23.2, 536/24.1, 800/288, 800/278, 800/287, 800/294, 800/295, 800/317.3, A61K38/00, C12Y302/01045, C12N9/2402, C12N15/8237, C12N15/8257, C12Y302/01018, C12Y302/01022, C12Y302/01024, C12Y302/01049, C12Y302/01076
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Patent . 1996
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