publication . Other literature type . Article . 2017

Interleukin-1 Antagonism Decreases Cortisol Levels in Obese Individuals.

Mirjam Christ-Crain;
Open Access
  • Published: 20 Feb 2017
  • Publisher: The Endocrine Society
  • Country: Switzerland
Abstract
Context: Increased cortisol levels in obesity may contribute to the associated metabolic syndrome. In obesity, the activated innate immune system leads to increased interleukin (IL)-1β, which is known to stimulate the release of adrenocorticotropin hormone (ACTH). Objectives: We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels. Design and Participants: In this prospective intervention study, we included 73 patients with obesity (body mass index [BMI] ≥30 kg/m2) and at least one additional feature of the metabolic syndrome. Outcome Measures: The primary end ...
Subjects
Medical Subject Headings: endocrine systemhormones, hormone substitutes, and hormone antagonists
free text keywords: Clinical Biochemistry, Biochemistry, Endocrinology, Diabetes and Metabolism, Endocrinology, Biochemistry, medical
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