publication . Other literature type . Thesis . 2006 . Embargo end date: 01 Jan 2006

Expression and regulation of transmembrane transporters in healthy intestine and gastrointestinal diseases

Huwyler, Jörg; Hruz, Petr; Drewe, Jürgen; Beglinger, Christoph;
  • Published: 01 Jan 2006
  • Publisher: (:unav)
  • Country: Switzerland
Transmembrane transporters mediate energy dependent or independent translocation of drugs, potentially toxic compounds, and of various endogenous substrates such as bile acids and bilirubin across membranes. In this thesis the focus is on two classes of transporters, the ATPbinding cassette (ABC) transporters, which mediate ATP dependent transport and the solute carriers (SLC) which use electrochemical gradients for their transport. The transporters are expressed on membranes of cells of excretory organs (e.g. kidney, liver) and protective barriers (e.g. intestine, blood brain barrier) and influence therefore the absorption, distribution and elimination of compo...
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Thesis . 2006
Provider: edoc
Other literature type . 2006
Provider: Datacite
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