publication . Doctoral thesis . 2002

Biocompatibility of orthopaedic implants on bone forming cells

Kapanen, A. (Anita);
Open Access English
  • Published: 22 Feb 2002
  • Publisher: University of Oulu
  • Country: Finland
Abstract Reindeer antler was studied for its possible use as a bone implant material. A molecular biological study showed that antler contains a growth factor promoting bone formation. Ectopic bone formation assay showed that antler is not an equally effective inducer as allogenic material. Ectopic bone formation assay was optimised for biocompatibility studies of orthopaedic NiTi implants. Ti-6Al-4V and stainless steel were used as reference materials. The assay showed differences in bone mineral densities, with superior qualities in NiTi. The rate of endochondral ossification varied between the implants, NiTi ossicles had larger cartilage and bone areas than o...
Medical Subject Headings: technology, industry, and agricultureequipment and supplies
free text keywords: biocompatible materials, bone morphogenetic proteins, cell death, focal adhesion, osteoblasts
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