publication . Doctoral thesis . 2014

Chronic lymphocytic leukemia: assessing pathogenesis and prognosis by modern molecular cytogenetic studies and microRNAs expression

Saccenti, Elena;
Open Access Italian
  • Published: 21 Mar 2014
  • Country: Italy
Abstract
Chronic lymphocytic leukemia (CLL) is a B-cell clonal lymphoprolipherative disorder characterized by the accumulation of small lymphocytes in the peripheral blood, bone marrow and lymph nodes deriving from the transformation of CD5+ B-cell. Despite a homogeneous immunophenotype consisting of CD19+, CD20+, CD5+ and CD23+, CLL is clinically heterogeneous. Several adverse prognostic features have been identified including stage, CD38 positivity, the unmutated configuration of the variable region of the immunoglobulin heavy chain gene (IGHV), ZAP70 positivity, chromosome aberrations and molecular abnormalities. Detailed immunophenotypic and genetic analysis allowed ...
Subjects
Medical Subject Headings: hemic and lymphatic diseasesimmune system diseases
free text keywords: MED/15 Malattie del sangue, leukemia, lymphocytic, chronic, MED/15
Related Organizations

3.3 Next-generation sequencing in CLL ....................................................................................... 61 3.3.1 Ion Torrent PGM (Personal Genome Machine) ................................................................... 64 3.3.2 Methods and results ............................................................................................................ 66

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