publication . Bachelor thesis . 2015

The role of cohesin genes in the meiosis of male house mouse

Šebestová, Lenka;
Restricted Czech
  • Published: 01 Jan 2015
  • Country: Czech Republic
Abstract
Cohesin genes play an important role in cell division. They ensure proper chromosome segregation during mitosis and meiosis. This study is focused on the role of cohesin genes during meiosis in male house mouse (Mus musculus). At first, this study introduces key processes of mammalian meiosis. Next, the structure of cohesin complex is described; it consists of a heterodimer SMC proteins - SMC3 and SMC1α or SMC1β, which are enclosed to the ring by cleavable subunit RAD21, RAD21L or REC8. Fourth subunit - a STAG protein (STAG1, STAG2 or STAG3) associates with the cleavable subunit. Meiotic function of specific cohesin proteins (SMC1β, RAD21L, REC8 and STAG3) as de...
Subjects
Medical Subject Headings: biological phenomena, cell phenomena, and immunity
free text keywords: Smc1b; Stag3; Rad21l; Rec8; Cohesin; meióza; meiosis; myš; Kohezin; spermatogenesis; spermatogeneze; mouse
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