publication . Doctoral thesis . 2015

Charakterizace nových proteinových interakcí gama-tubulinu a jejich funkce s mikrotubuly a v buněčném dělení

Kohoutová, Lucie;
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  • Published: 01 Jan 2015
  • Country: Czech Republic
Abstract
Spatial and temporal regulation of microtubule nucleation and dynamics is required for formation of specific microtubular arrays that react to internal and external signals and change accordingly. Microtubules are nucleated from microtubule-organizing centres such as centrosomes in animal cells or spindle pole bodies in fungi. All higher plants lack centrosomes and thus present a model for study of acentrosomal cell division and microtubule nucleation and organization. γ-Tubulin is a conserved protein from tubulin superfamily with a central role in microtubule nucleation. It also regulates microtubule dynamics and organization including mitotic spindle positioni...
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