Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody I
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Pharmacy Candidate: Kristýna Navrátilová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antibacterial substan- ces through the use of microdilution broth method I Background Development of new antibacterial agents is still and will be always an impor- tant area of pharmaceutical industry. The need to discover new drugs is growing resistance of pathogenic bacterial strains. Aim of the work was to test new potencial antibacterial active substances on antimicrobial activity. Methods As part of this thesis was by using microdilution broth method tested for antibac- terial activity against eight chosen bacterial strains 106 chemicals newly synthesized by the Departments of the Faculty of Pharmacy in Hradec Králové. The described method is used as a screening for pre-determining of the effectiveness of antimicro- bial agents. Results Substances were divided into ten groups according to chemical structure. The most effective was reflected group of salicylthioamid derivates. These substances belong to this group inhibited bacterial growth of all tested strains by very low concentrations already. For each tested bacterial strain...