Detekce polymorfismu v genu MDR1 u ovčáckých a honáckých psů

Master thesis Czech RESTRICTED
Staroveská, Marieta;
  • Subject: membránový transportér; Canis lupus familiaris; P-glykoprotein; farmakogenetika; léková rezistence; hypersenzitivita; ABCB1; ivermektin; polymorfismus; MDR1 gen

This thesis is focused on polymorphism of MDR1 gene and related drug resistance. Resistance is caused by deletion of four nucleotids, that resulting in a frame shift and synthesis of nonfunctional transport of P-glycoprotein. The text describes a polymorphism of MDR1 (A... View more
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