publication . Master thesis . 2012

Translokáza proteinů do mitosomů Giardia intestinalis.

Fixová, Ivana;
Restricted Czech
  • Published: 01 Jan 2012
  • Country: Czech Republic
During the transformation of the bacterial endosymbiont into current mitochondria the protein import apparatus had to be created de novo. The reduced mitochondria (mitosomes) of the parasitic protist Giardia intestinalis represent unique cellular model for the examination of these fundamental transport processes. As the main objective of this project I will try to characterize the motor complex, which propels the protein transport, and also the translocation channel in the inner mitosomal membrane. To this aim I will exploit the presence of two membrane components Pam16 and Pam18, which were discovered in our laboratory, and which constitute the functional core ...
free text keywords: PAM complex; mitosom; PAM komplex; import proteinů; BN-PAGE; protein import; Giardia intestinalis
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