publication . Master thesis . 2013

Study on the interaction of chemopreventive compounds and food born carcinogens with cytochrome P450 enzymes

Brabencová, Eliška;
Restricted Czech
  • Published: 01 Jan 2013
  • Country: Czech Republic
Abstract
The use of food supplements containing natural chemopreventive compounds increased in recent years. Some of the most popular chemopreventive compounds are flavonoids. Due to their natural origin, flavonoids are generally accepted as safe compounds. They exert antioxidant, anti-cancer and anti-inflammatory properties. However, flavonoids should be considered as foreign compounds (xenobiotics). Flavonoids interact with many enzymes, among the most important belong cytochromes P450 (CYPs), key enzymes of the first phase of biotransformation of xenobiotics (e.g. drugs, carcinogens). CYPs catalyze reactions leading mainly to detoxification of xenobiotics. However, so...
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Subjects
Medical Subject Headings: heterocyclic compoundsfood and beveragesrespiratory system
free text keywords: carcinogens; cytochrom P450; flavonoids; flavonoidy; karcinogeny; Western blotting; chemoprevention; cytochrome P450; "Western blotting"; chemoprevence
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Master thesis . 2013
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