publication . Article . 2016

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice

Danzer C; Koller A; Baier J; Arnold H; Giessler C; Opoka R; Schmidt S; Willers M; Mihai S; Parsch H; ...
Open Access English
  • Published: 01 Jun 2016
  • Country: Germany
Abstract
TCR ligation is critical for the selection, activation, and integrin expression of T lymphocytes. Here, we explored the role of the TCR adaptor protein slp-76 on iNKT-cell biology. Compared to B6 controls, slp-76ace/ace mice carrying a missense mutation (Thr428Ile) within the SH2-domain of slp-76 showed an increase in iNKT cells in the thymus and lymph nodes, but a decrease in iNKT cells in spleens and livers, along with reduced ADAP expression and cytokine response. A comparable reduction in iNKT cells was observed in the livers and spleens of ADAP-deficient mice. Like ADAP−/− iNKT cells, slp-76ace/ace iNKT cells were characterized by enhanced CD11b expression,...
Subjects
free text keywords: -, Medizinische Fakultät, ddc:610
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