Modeling neurodevelopment and cortical dysfunction in SPG11-linked hereditary spastic paraplegia using human induced pluripotent stem cells

Doctoral thesis English OPEN
Mishra, Himanshu Kumar;
(2016)
  • Subject: SPG11 | neurodevelopment | iPSC | neurodegeneration | Naturwissenschaftliche Fakultät
    • ddc: ddc:570 | ddc:610

Hereditary spastic paraplegias (HSPs) are a heterogeneous group of inherited motor neuron diseases characterized by progressive spasticity and weakness of the lower limbs. Mutations in the Spastic Paraplegia Gene11 (SPG11), encoding spatacsin, cause the most frequent fo... View more
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