publication . Thesis . Other literature type . 2017

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Mak, Plato;
  • Published: 23 Feb 2017
For over a decade, many clinics have offered multiday infusions of ketamine in conjunction with opioids as an off-label treatment for intractable chronic pain. Originally termed “burst ketamine” (BK), the proposed therapeutic effects of this treatment are to (1) provide lasting pain relief otherwise unattainable with standard pharmacotherapy, and (2) reduce opioid tolerance and thereby improve analgesic opioid response (i.e. an opioid dose-sparing effect). Although the use of BK is increasing, its efficacy is debated. This is due to the variability of outcomes reported in the limited clinical literature, and the absence of preclinical evidence investigating this...
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free text keywords: Uncategorized, Ketamine, Burst ketamine, Chronic pain, 1959.1/1232241, Opioids, Neuropathy, monash:163874, thesis(doctorate), Preclinical, ethesis-20160114-153443, Clinical, Translational, Restricted access, 2016
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Thesis . 2017
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Other literature type . 2017
Provider: Datacite
Thesis . 2017
Provider: figshare
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