publication . Thesis . Other literature type . 2017

Effects of prenatal nicotine and inflammation on respiratory function and structure in the newborn

Samarasinghe, Ayabaddage Thilini Damsarani;
English
  • Published: 27 Feb 2017
Abstract
This thesis was broadly directed at understanding how maternal inflammation and smoking have a deleterious impact on the development of the fetus and newborn. The studies outlined in this thesis showed that the two insults harm the fetus and newborn by reducing growth, by increasing the likelihood of preterm birth, and by adversely affecting lung development and the control of breathing by increasing the propensity for unstable breathing patterns and apnea in surviving pups. When the dose of nicotine given to pregnant mice matched that present in the blood of a heavy smoker, almost all the offspring died on the day of delivery. Alarmingly, maternal infection and...
Subjects
free text keywords: Uncategorized, nicotine, thesis(doctorate), 1959.1/1241114, lung development, ethesis-20160208-235910, monash:165971, respiratory function, maternal inflammation, restricted access, 2016
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http://dx.doi.org/10.4225/03/5...
Other literature type . 2017
Provider: Datacite
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Thesis . 2017
Provider: FigShare
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