publication . Other literature type . 2018

Presentation3.PDF

Garzón-Ospina, Diego; Buitrago, Sindy P.; Ramos, Andrea E.; Patarroyo, Manuel A.;
Open Access English
  • Published: 25 Jan 2018
Abstract
<p>Parasite antigen genetic diversity represents a great obstacle when designing a vaccine against malaria caused by Plasmodium vivax. Selecting vaccine candidate antigens has been focused on those fulfilling a role in invasion and which are conserved, thus avoiding specific-allele immune responses. Most antigens described to date belong to the blood stage, thereby blocking parasite development within red blood cells, whilst studying antigens from other stages has been quite restricted. Antigens from different parasite stages are required for developing a completely effective vaccine; thus, pre-erythrocyte stage antigens able to block the first line of infection...
Subjects
free text keywords: Genetics, Plasmodium vivax, genetic diversity, sporozoite, vaccine, natural selection, hepatocyte invasion
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Other literature type . 2018
Provider: FigShare
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