publication . Other literature type . 2017

Regulation of leptin and insulin signaling by the t cell protein tyrosine phosphatase

Loh, Kim Yong;
Open Access English
  • Published: 09 Feb 2017
  • Publisher: Monash University
Abstract
The prevalence of obesity and diabetes are increasing at alarming rates. Both are major health concerns worldwide. Food intake, energy expenditure and hepatic glucose production are regulated by hypothalamic neuronal circuits that respond to peripheral signals including leptin and insulin. Leptin is produced by adipose tissue and acts in the hypothalamus via the JAK2/STAT3 signaling pathway to decrease food intake and increase energy expenditure. It is now also widely appreciated that insulin acts in the hypothalamus to control whole body glucose homeostasis, particularly hepatic glucose production. A key negative regulator of leptin and insulin signaling is the...
Subjects
mesheuropmc: digestive, oral, and skin physiologyhormones, hormone substitutes, and hormone antagonists
free text keywords: monash:81767, thesis(doctorate), 2011, Uncategorized, ethesis-20120227-164229, tcptp, 1959.1/537519, restricted access, obesity
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Other literature type . 2017
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Other literature type . 2017
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publication . Other literature type . 2017

Regulation of leptin and insulin signaling by the t cell protein tyrosine phosphatase

Loh, Kim Yong;