publication . Thesis . Other literature type . 2018

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JESSICA CLAIRE ANANIA;
English
  • Published: 11 Jan 2018
Abstract
Leukocyte Fc receptors (FcR) bind to immunogloulins (Ig) to link the innate and humoral immune system to help balance the immune system and clear infections. We have characterised a novel FcR for IgG (FcγR) form, designated FcγRIIa3, which contains a 19 amino acid insert. This insert interacts with cytoskeletal structures allowing the receptor to be retained for longer periods of time at the cells surface upon activation, higher cell signalling which causes greater cellular activation. Therefore, individuals who express this FcγRIIa3 may be predisposed to pro-inflammatory disease.
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Subjects
Medical Subject Headings: chemical and pharmacologic phenomena
free text keywords: Immunology, Fc Receptors, Antibodies, Inflammatory disease, FOS: Clinical medicine
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http://dx.doi.org/10.4225/03/5...
Other literature type . 2018
Provider: Datacite
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Thesis . 2018
Provider: FigShare
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Thesis . 2018
Provider: figshare
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