publication . Conference object . 2014

The expression of the soluble HFE corresponding transcript is up-regulated by intracellular iron and inhibits iron absorption in a duodenal cell model

Silva, Bruno; Ferreira, Joana; Santos, Vera; Baldaia, Cilénia; Serejo, Fátima; Paula Faustino;
Open Access English
  • Published: 01 Apr 2014
  • Country: Portugal
Abstract
Background and aims: Dietary iron absorption regulation is a key-step for the maintenance of body iron homeostasis. Besides the HFE full-length protein, the HFE gene codes for alternative splicing variants responsible for the synthesis of a soluble form of HFE protein (sHFE). Here we aimed to determine whether sHFE transcript levels respond to different iron conditions in duodenal, macrophage and hepatic cell models, as well, in vivo, in the liver. Furthermore, we determined the functional effect of the sHFE protein on the expression of iron metabolism-related genes in a duodenal cell model. Methods: The levels of sHFE transcripts were measured in HuTu-80, activ...
Subjects
free text keywords: Metabolismo do Ferro, HFE, Hemocromatose Hereditária, Doenças Genéticas
Funded by
FCT| PTDC/SAU-GMG/64494/2006
Project
PTDC/SAU-GMG/64494/2006
Study of post-transcriptional regulation of HFE gene expression - a contribution to understand its role in iron homeostasis and in Hereditary Hemochromatosis development
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 64494
  • Funding stream: 3599-PPCDT
,
FCT| PTDC/SAU-GMG/103307/2008
Project
PTDC/SAU-GMG/103307/2008
Role of the iron metabolism on the progression of hepatitis C viral infection and treatment response
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 103307
  • Funding stream: 3599-PPCDT
,
FCT| SFRH/BD/60718/2009
Project
SFRH/BD/60718/2009
THE FUNCTIONAL LINK BETWEEN HFE AND HEPCIDIN - ITS CONTRIBUTION TO IRON METABOLISM REGULATION
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/60718/2009
  • Funding stream: SFRH | Doutoramento
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publication . Conference object . 2014

The expression of the soluble HFE corresponding transcript is up-regulated by intracellular iron and inhibits iron absorption in a duodenal cell model

Silva, Bruno; Ferreira, Joana; Santos, Vera; Baldaia, Cilénia; Serejo, Fátima; Paula Faustino;