publication . Conference object . 2014

The soluble HFE isoform – a regulator of iron absorption in the duodenum

Silva, Bruno; Ferreira, Joana; Santos, Vera; Sousa, Patícia; Baldaia, Cilénia; Serejo, Fátima; Paula Faustino;
  • Published: 01 Sep 2014
  • Country: Portugal
Abstract
Objective: Dietary iron absorption regulation is a key-step for body iron homeostasis. Once inside the enterocyte, iron is directed to the basolateral membrane being oxidized by hephaestin, which mediates iron efflux towards circulatory transferrin in cooperation with ferroportin. Besides the HFE full-length protein, the HFE gene codes for alternative splicing transcripts responsible for the synthesis of a soluble form of HFE protein (sHFE). The main objective of this work was to assess whether sHFE plays a role in iron absorption regulation in duodenum. In particular, we intended to determine if sHFE transcript levels respond to different iron conditions in duo...
Subjects
Medical Subject Headings: digestive, oral, and skin physiology
free text keywords: Metabolismo do Ferro, HFE, Isoforma, Endocitose, Duodeno, Ferro, Doenças Genéticas
Funded by
FCT| PTDC/SAU-GMG/64494/2006
Project
PTDC/SAU-GMG/64494/2006
Study of post-transcriptional regulation of HFE gene expression - a contribution to understand its role in iron homeostasis and in Hereditary Hemochromatosis development
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 64494
  • Funding stream: 3599-PPCDT
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publication . Conference object . 2014

The soluble HFE isoform – a regulator of iron absorption in the duodenum

Silva, Bruno; Ferreira, Joana; Santos, Vera; Sousa, Patícia; Baldaia, Cilénia; Serejo, Fátima; Paula Faustino;