publication . Doctoral thesis . 2013

The functional link between HFE and hepcidin- its contribution to iron metabolism regulation

Silva, Bruno Adriano de Sousa, 1985-;
Open Access English
  • Published: 01 Jan 2013
  • Country: Portugal
Abstract
Tese de doutoramento, Biologia (Biologia Molecular), Universidade de Lisboa, Faculdade de Ciências, 2013 Iron is essential for several vital biological processes. Its deficiency and overload drive to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is prompted by increased iron levels. It targets the iron exporter ferroportin-1, blocking iron release from cells. Hepcidin expression is regulated by HFE, on an iron-dependent manner. Besi...
Subjects
Medical Subject Headings: nutritional and metabolic diseasescongenital, hereditary, and neonatal diseases and abnormalities
free text keywords: Metabolismo do ferro, Hepcidina, Hemocromatose, Teses de doutoramento - 2013
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