publication . Doctoral thesis . 2002

Novel aspects of Na+,K+-ATPase

  • Published: 13 Sep 2002
  • Country: Sweden
Abstract
Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation. It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. New findings in this study are: 1) the level of intracellular Ca 2. concentration determines the functional effects of PKA and PKC-mediated Na,K-ATPase phosphorylation. At low [Ca 2+]i , activation of PKA or PKC resulted in inhibition of Na,K-ATPase activity, while at high (Ca 2+]i a stimulatory effect was observed. 2) Dynamic regulation of ...
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