publication . Doctoral thesis . 2007

Clinical studies of biomarkers in suicide prediction

  • Published: 19 Oct 2007
  • Country: Sweden
Abstract
Suicide is a major clinical problem in psychiatry and suicidal behaviours can be seen as a nosological entity per se. Predicting suicide is difficult due to its low base-rate and the limited specificity of clinical predictors. Prospective biological studies suggest that dysfunctions in the hypothalamo pituitary adrenal (HPA) axis and the serotonergic system have predictive power for suicide in mood disorders. Suicide attempt is the most robust clinical predictor making suicide attempters a clinical high-risk group. A prediction model that incorporates biological testing to increase specificity and sensitivity of prediction of suicide risk is of potential clinica...
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