publication . Doctoral thesis . 2014

Inflammation, caffeine and adenosine in neonatal hypoxic ischemic brain injury

Winerdal, Max;
English
  • Published: 01 Jan 2014
  • Publisher: Karolinska Institutet, Dept of Women's and Children's Health
Abstract
Background: Brain injury during the neonatal period has potentially lifelong consequences for a child. Perinatal infections and inflammation can induce preterm birth and unfavorable cognitive development, Thus inflammation has received enthusiastic interest for potential therapeutic approaches seeking to protect the newborn brain. Experimental evidence demonstrates that inflammation induces brain injury succeeding the initial insult. A key cytokine in brain injury is the tumor necrosis factor (TNF-α), with reported detrimental cytotoxic effects on selected neuronal populations. Nonetheless, important functions of TNF-α in cerebral homeostasis and development hav...
Subjects
free text keywords: MEDICAL AND HEALTH SCIENCES, MEDICIN OCH HÄLSOVETENSKAP
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