publication . Doctoral thesis . 2005

Cell cycle control by components of cell anchorage

  • Published: 05 Aug 2005
  • Country: Sweden
Abstract
Extracellular factors, such as growth factors and cell anchorage to the extracellular matrix, control when and where cells may proliferate. This control is abolished when a normal cell transforms into a tumour cell. The control of cell proliferation by cell anchorage was elusive and less well studied than the control by growth factors. Therefore, we aimed to clarify at what points in the cell cycle and through which molecular mechanisms cell anchorage controls cell cycle progression. In addition, we wanted to clarify if two components involved in cell anchorage, the hyaluronic acid (HA) -binding domain of CD44 and p21-activated kinase 1 (PAK1), can control cell ...
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