publication . Doctoral thesis . 2007

Strategies to improve macroencapsulated islet graft survival

Sörenby, Anne;
English
  • Published: 01 Jan 2007
  • Publisher: Karolinska Institutet, Department of Clinical Sciences
  • Country: Sweden
Abstract
Chronic immunosuppressive therapy may have severe side-effects. In cell transplantation, the graft can be encapsulated within a membrane chamber, providing a physical barrier against the immune system. The cell graft then becomes dependent on the diffusion of nutrients and oxygen from the surrounding microcirculation. A major drawback has been the formation of avascular fibrotic tissue around the chamber. The immunoprotective device studied (TheraCyte ) has an outer membrane inducing neovascularization. However, major parts of the encapsulated graft are still lost soon after transplantation, probably because of relative hypoxia and malnutrition. The overall aim ...
Subjects
Medical Subject Headings: endocrine system
free text keywords: MEDICAL AND HEALTH SCIENCES, MEDICIN OCH HÄLSOVETENSKAP
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